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BPS BPS-Pharmacotherapy Exam Syllabus Topics:

BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. From ethical and scientific validity standpoints, in addition to double blinding, which of the following research designs is best for determining a new medication's relative efficacy in treating acute stroke?

A) Placebo-controlled, crossover design
B) Parallel design comparing the new therapy with the best standard therapy
C) Placebo-controlled, randomized, parallel design
D) Crossover design comparing the new therapy with the best standard therapy

2. A 65-year-old man presents to the internal medicine clinic with decreased exercise tolerance, lower extremity edema, and shortness of breath.
He has a history of diastolic dysfunction (ejection fraction of 60%) and hypertension; BP =
150/90 mm Hg, HR = 86 bpm.
Current medications include digoxin 125 mcg daily, furosemide 40 mg daily, enalapril 10 mg twice daily, aspirin 325 mg daily, and potassium 10 mEq twice daily. The digoxin concentration is 0.4 ng/mL.
After resolution of this exacerbation, which of the following should the pharmacotherapy specialist recommend to the internist regarding this patient's maintenance drug therapy?

A) Increase digoxin.
B) Discontinue digoxin and add amlodipine.
C) Discontinue digoxin and add metoprolol.
D) Increase furosemide.

3. A 42-year-old woman is diagnosed with deep vein thrombosis. Heparin therapy is initiated with
5,000 units as a single bolus injection, followed by an initial infusion rate of 1,000 units/h. The aPTT measured 6 hours later is >150 sec. Which of the following would be the most appropriate action at this time?

A) Stop the infusion for one hour, then resume at 750 units/h.
B) Administer protamine 5 mg, and decrease the infusion rate to 750 units/h.
C) Stop the infusion until the aPTT falls to <50 sec, and then resume at 750 units/h.
D) Continue the infusion at 1,000 units/h, since the aPTT was drawn too early and is not useful.

4. To correct the development of metabolic acidosis in patients receiving standard TPN solutions, which of the following is the best therapeutic intervention?

A) Hyperventilate the patient to produce hypocapnia.
B) Decrease the phosphate and add bicarbonate.
C) Decrease the potassium and increase the calcium.
D) Decrease the chloride and increase the acetate.

5. A new team has been established in a large healthcare system to conduct research. At the first meeting of the new team, the pharmacotherapy specialist was asked to submit a proposal for a randomized clinical study. What is the first step in formulating the research hypothesis for this proposal?

A) Selecting a viable intervention
B) Selecting an appropriate comparator
C) Formulating an answerable question
D) Determining a measurable outcome

Solutions: